Louisville guard Reyne Smith tried to play through injury, but his right ankle gave way in the second half as the Cardinals’ season came to an end with an 89-75 loss to Creighton on Thursday.

Smith collapsed into the fetal position with 11:37 left in the Cardinals’ first-round game. He had missed Louisville’s past four games due to the injury, sitting out the regular-season finale and all three games at the ACC tournament, including the team’s first appearance in the title game.

With Smith curled up on the court and visibly upset across from the Louisville bench, his teammates hugged each other while surrounding him. First-year coach Pat Kelsey knelt over Smith before signaling for a towel.

Smith put the towel over his head then was helped off the court, barely able to put any weight on his right foot.

The senior from Australia started and played 20 minutes before aggravating his injured ankle. He left with five points.

The Associated Press contributed to this report.